Euphane triterpenoids of Cassipourea lanceolata from the Madagascar rainforest |
| |
| Authors: | Yanpeng Hou Shugeng Cao Peggy J. Brodie James S. Miller Chris Birkinshaw Mamisoa N. Andrianjafy Rabodo Andriantsiferana Vincent E. Rasamison Karen TenDyke Yongchun Shen Edward M. Suh David G.I. Kingston |
| |
| Affiliation: | 1. Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061-0212, USA;2. Missouri Botanical Garden, P.O. Box 299, St. Louis, MO 63166-0299, USA;3. Missouri Botanical Garden, B.P 3391, Antananarivo 101, Madagascar, USA;4. Centre National d’Application et Recherches Pharmaceutiques, B.P 702, Antananarivo 101, Madagascar, USA;5. Eisai Inc., 4 Corporate Drive, Andover, MA 01810, USA |
| |
| Abstract: | Fractionation of an ethanol extract of a Madagascar collection of the leaves and fruit of Cassipourea lanceolata Tul. led to the isolation of three euphane triterpenoids 1–3. The 1H and 13C NMR spectra of all compounds were fully assigned using a combination of 2D NMR experiments, including COSY, TOCSY, HSQC (HMQC), HMBC and ROESY sequences. The three compounds showed weak antiproliferative activities against the A2780 human ovarian cancer cell line, with IC50 values of 25, 25 and 32 μM, respectively. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
