Cembranolides from the stem bark of the southern African medicinal plant,Croton gratissimus (Euphorbiaceae) |
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| Authors: | Dulcie A. Mulholland Moses K. Langat Neil R. Crouch Helen M. Coley Emily M. Mutambi Jean-Marc Nuzillard |
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| Affiliation: | 1. Division of Chemical Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, Surrey, UK;2. School of Chemistry, University of KwaZulu-Natal, Durban 4041, South Africa;3. Ethnobotany Unit, South African National Biodiversity Institute, PO Box 52099, Berea Road 4007, Durban, South Africa;4. Division of Biochemical Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH Surrey, UK;5. University of Bristol, School of Chemistry, Cantocks Close, BS8 1TS Bristol, UK;6. Pharmacognosy Laboratory, University of Reims, Moulin de la House, BP 1039, 51687 Reims Cedex 2, France |
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| Abstract: | The stem bark of Croton gratissimus (Euphorbiaceae) yielded four cembranolides, including the first reported example of a 2,12-cyclocembranolide, (+)-[1R*,2S*,7S*,8S*,12R*]-7,8-epoxy-2,12-cyclocembra-3E,10Z-dien-20,10-olide, whose structure was confirmed by means of single crystal X-ray analysis. This compound showed moderate activity against the PEO1 and PEO1TaxR ovarian cancer cell lines. |
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