Zierane sesquiterpene lactone,cembrane and fusicoccane diterpenoids,from the Tahitian liverwort Chandonanthus hirtellus |
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| Authors: | Ismiarni Komala Takuya Ito Fumihiro Nagashima Yasuyuki Yagi Masatoshi Kawahata Kentaro Yamaguchi Yoshinori Asakawa |
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| Institution: | 1. Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan;2. Faculty of Pharmaceutical Sciences at Kagawa, Tokushima Bunri University, Sanuki-city, Kagawa 769-2193, Japan;3. Pharmacy Department, Faculty of Medicine and Health Sciences, Syarif Hidayatullah State Islamic University, Jl. Ir. H. Juanda No. 95 Ciputat 15412, Jakarta, Indonesia |
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| Abstract: | Cembrane-type diterpenoids, 13,18,20-epi-iso-chandonanthone (1) and (8E)-4α-acetoxy-12α,13α-epoxycembra-1(15),8-diene (2), two fusicoccane-type diterpenoids, fusicoauritone 6α-methyl ether (3) and 6β,10β-epoxy-5β-hydroxyfusicocc-2-ene (4) and a zierane sesquiterpene γ-lactone, chandolide (5) were isolated from the Tahitian liverwort Chandonanthus hirtellus (Web.) Mitt., together with eight known diterpenoids, chandonanthine (6), fusicogigantone A (7), fusicogigantone B (8), fusicogigantepoxide (9), anadensin (10), fusicoauritone (11), ent-verticillol (12) and ent-epi-verticillol (13). Their structures were established by a combination of extensive NMR spectroscopy and/or X-ray crystallographic analyses. Compounds 1, 5 and 10 showed weak cytotoxic activity against HL-60. Compound 3 also indicated weak cytotoxic activity against KB cell lines. |
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