Microbial metabolism of cannflavin A and B isolated from Cannabis sativa |
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| Authors: | Amany K Ibrahim Mohamed M Radwan Safwat A Ahmed Desmond Slade Samir A Ross Mahmoud A ElSohly Ikhlas A Khan |
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| Institution: | 1. Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt;2. National Center for Natural Products Research, School of Pharmacy, University of Mississippi, MS 38677, USA;3. Department of Pharmacognosy, School of Pharmacy, University of Mississippi, MS 38677, USA;4. Department of Pharmaceutics, School of Pharmacy, University of Mississippi, MS 38677, USA |
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| Abstract: | Microbial metabolism of cannflavin A (1) and B (2), two biologically active flavonoids isolated from Cannabis sativa L., produced five metabolites (3–7). Incubation of 1 and 2 with Mucor ramannianus (ATCC 9628) and Beauveria bassiana (ATCC 13144), respectively, yielded 6″S,7″-dihydroxycannflavin A (3), 6″S,7″-dihydroxycannflavin A 7-sulfate (4) and 6″S,7″-dihydroxycannflavin A 4′-O-α-l-rhamnopyranoside (5), and cannflavin B 7-O-β-d-4?-O-methylglucopyranoside (6) and cannflavin B 7-sulfate (7), respectively. All compounds were evaluated for antimicrobial and antiprotozoal activity. |
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