Convenient synthesis and in vitro pharmacological activity of 2-thioanalogs of salvinorins A and B |
| |
| Authors: | Bikbulatov Ruslan V Yan Feng Roth Bryan L Zjawiony Jordan K |
| |
| Affiliation: | Department of Pharmacognosy, School of Pharmacy, University of Mississippi, University, MS 38677-1848, USA. |
| |
| Abstract: | To study drug-receptor interactions, new thio-derivatives of salvinorin A, an extremely potent natural kappa-opioid receptor (KOR) agonist, were synthesized. Obtained compounds were examined for receptor binding affinity. Analogs with the same configuration at carbon atom C-2 as in natural salvinorin A showed higher affinity to KOR than their corresponding epimers. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
