Pharmacological differentiation between the chemotactic factor induced intracellular calcium redistribution and transmembrane calcium influx in rabbit neutrophils. |
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| Authors: | P H Naccache H J Showell E L Becker R I Sha'afi |
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| Institution: | 1. Department of Physiology, University of Connecticut Health Center Farmington, Connecticut 06032 USA;2. Department of Pathology, University of Connecticut Health Center Farmington, Connecticut 06032 USA |
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| Abstract: | Nordihydroguaiaretic acid selectively inhibits the chemotactic factor induced stimulation of calcium influx and increase in the steady-state level of cell-associated 45Ca observed in the presence of calcium in rabbit peritoneal neutrophils. On the other hand nordihydroguaiaretic acid does not inhibit the transient decreases in the steady state levels of 45Ca observed either in the presence of low extracellular calcium or of low concentrations of chemotactic factors. These results suggest that nordihydroguaiaretic acid does not affect the intracellular calcium redistribution which is induced by chemotactic factors but rather it inhibits the influx of extracellular calcium which accompanies stimulation. |
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