Molecular modelling studies of four stranded quadruplexes containing a 3'-3' or 5'-5' inversion of polarity site |
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| Authors: | Virno Ada Zaccaria Francesco Virgilio Antonella Esposito Veronica Galeone Aldo Mayol Luciano Randazzo Antonio |
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| Institution: | Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli Federico II, Napoli, Italy. |
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| Abstract: | Recently we reported a preliminary study on the structure of two novel quadruplex structures, Q33 and Q55, formed by the oligodeoxynucleotides (5)'TGG(3)'-(3)'GGT(5)' and (3)'TGG(5)'-(5)'GGT(3)', respectively. Here we report their solution structures at the atomic level. The obtained structures reveal that Q55 and Q33 possess a different stacking among G-quartets and different twist angle (and therefore different helical winding) at the inversion of polarity level. |
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