Arrested development of the rabbit stomach worm Obeliscoides cuniculi: resumption of development of arrested larvae throughout the course of a single infection |
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| Authors: | A R Watkins M A Fernando |
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| Affiliation: | 1. Center for Research in Health Technologies and Information Systems – CINTESIS, Universidade do Porto, Porto, Portugal;2. Allergy and Clinical Immunology Department, Hospital CUF-Descobertas, Lisboa, Portugal;3. Sociedade Portuguesa de Alergologia e Imunologia Clínica, Lisbon, Portugal;4. Immunology Department, Faculdade de Medicina da Universidade do Porto, Porto, Portugal;5. Health Information and Decision Sciences Department – CIDES, Faculdade de Medicina, Universidade do Porto, Porto, Portugal;6. Allergy Unit, Instituto CUF Porto e Hospital CUF Porto, Porto, Portugal;7. Comissão de Acompanhamento do Programa Nacional de Controlo da Asma, Lisbon, Portugal;8. Hôpital Arnaud de Villeneuve, Centre Hospitalier Universitaire Montpellier, Montpellier, France;9. Centre de recherche en Epidémiologie et Santé des Populations – CESP Inserm U1018, Villejuif, France |
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| Abstract: | Arrested development of the rabbit stomach worm Obeliscoides cuniculi: resumption of development of arrested larvae throughout the course of a single infection. International Journal for Parasitology 16: 47–54. Twenty rabbits were inoculated once with cold treated L3s of Obeliscoides cuniculi with a high propensity for arrest and killed in pairs at intervals over 234 days post-infection. An exponential decline in numbers of adult worms and arrested larvae was observed. Arrested larvae resumed development at a rate seven times greater than adults were lost and appeared to replenish the adult population. More male than female arrested larvae were intially established in rabbits but males resumed development at a greater rate than females. Egg and larval production were correlated with the number of female worms present at any one time. In a subsidiary study, arrested larvae were recovered from one rabbit and transferred sequentially through two further rabbits. These larvae resumed development at the same rate as larvae in the 20 rabbits. Both studies suggest that resumption of development is an intrinsic characteristic of the larvae themselves and may be genetically controlled. |
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