Inheritance of migraine investigated by complex segregation analysis |
| |
| Authors: | Michael Bjørn Russell Lennart Iselius Jes Olesen |
| |
| Affiliation: | (1) Department of Neurology, Glostrup Hospital, University of Copenhagen, DK-2600 Glostrup, Denmark;(2) The Glostrup Population Studies, Department of Internal Medicine C, Glostrup Hospital, University of Copenhagen, DK-2600 Glostrup, Denmark;(3) Department of Surgery, Karolinska Hospital, S-17176 Stockholm, Sweden |
| |
| Abstract: | Migraine is the most common neurological disorder, affecting about 20% of adults. The mode of inheritance was analyzed in the two main types of migraine, migraine without aura (MO) and migraine with aura (MA), by complex segregation analysis using the computer program POINTER. We included 126 probands with MO and 127 probands with MA from the general population. Firstdegree relatives and spouses were blindly interviewed by a neurological research fellow. The complex segregation analysis indicated that both MO and MA have multifactorial inheritance without generational difference. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
