Localization of human antigen-specific helper and suppressor function in distinct T-cell subpopulations. |
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| Authors: | C J Heijnen F UytdeHaag F H Gmelig-Meyling R E Ballieux |
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| Affiliation: | 1. Department of Immunology, University Children''s Hospital, Het Wilhelmina Kinderziekenhuis, Utrecht, The Netherlands;2. Department of Clinical Immunology, University Hospital, Utrecht, The Netherlands |
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| Abstract: | Distinct human T-cell subpopulations were isolated and cultured in the presence of B-cells and antigens. After an incubation period of 6 days cells were tested for their capacity to secrete antigen-specific antibodies in the PFC-assay. The results indicate that the T-helper activity for the antigen-induced T-dependent B-cell differentiation is located in the Tμ-subpopulation, whereas the suppressor-cell activity is confined to the Tγ-subpopulation. |
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