Mammalian FMRF-NH2-like peptide in rat pituitary: decrease by osmotic stimulus. |
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| Authors: | Elizabeth A. Majane and Hsiu-Ying T. Yang |
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| Affiliation: | Laboratory of Biochemical Genetics, NIMH Neuroscience Center at St. Elizabeths, Washington, DC 20032, USA |
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| Abstract: | Previous studies with the Brattleboro rat suggested a possible interaction at the pituitary level between AVP and the neuropeptide, F-8-F-NH2. In order to test this hypothesis, we studied the effect of various osmotic stimuli on neurohypophyseal F-8-F-NH2. In rats drinking 2% NaCl solution for two days, neural lobe AVP and F-8-F-NH2 levels were equally reduced by 87%. After maximal depletion, pituitary levels of F-8-F-NH2 and AVP rebounded in parallel when normal drinking water was reintroduced. Pituitary stalk transection depleted neurohypophyseal F-8-F-NH2. The results of this study suggest that neurohypophyseal F-8-F-NH2 originates from the hypothalamus and, furthermore, is coreleased along with AVP in response to hyperosmotic stimuli. |
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| Keywords: | FMRF-NH2-like F-8-F-NH2 Pituitary Hyperosmotic stimuli AVP Coregulation |
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