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Synthesis of a glycolipid for studying mechanisms of mitochondrial uncoupling proteins |
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| Authors: | Gouin Sebastien G Pilgrim Wayne Porter Richard K Murphy Paul V |
| Affiliation: | Centre for Synthesis and Chemical Biology, Department of Chemistry, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Ireland. |
| Abstract: | Glucose-O-omega-palmitic acid is an amphipathic molecule that is useful as a tool for studying the mechanism of mitochondrial uncoupling proteins. The synthesis of this glycolipid is described herein. The study of the reaction of a series of glycosyl donors with appropriate acceptors derived from 16-hydroxyhexadecanoic acid showed that a glycosyl trichloroacetimidate donor was more efficient than thioglycoside, glycosyl halide and glycosyl acetate donors for synthesis of this glycolipid. |
| Keywords: | Mitochondrial uncoupling protein Glycoconjugates Glucose-O-ω-palmitic acid Palmitic acid 16-(β- smallcaps" >d-Glucopyranosyloxy)-hexadecanoic acid |
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