Neurotrophic factors and their receptors in axonal regeneration and functional recovery after peripheral nerve injury |
| |
Authors: | Boyd J Gordon Gordon Tessa |
| |
Institution: | (1) Department of Anatomy and Cell Biology, Queen’s University, Kingston, ON, Canada;(2) University Centre for Neuroscience, University of Alberta, Edmonton, AB, Canada |
| |
Abstract: | Over a half a century of research has confirmed that neurotrophic factors promote the survival and process outgrowth of isolated
neurons in vitro. The mechanisms by which neurotrophic factors mediate these survival-promoting effects have also been well
characterized. In vivo, peripheral neurons are critically dependent on limited amounts of neurotrophic factors during development.
After peripheral nerve injury, the adult mammalian peripheral nervous system responds by making neurotrophic factors once
again available, either by autocrine or paracrine sources. Three families of neurotrophic factors were compared, the neurotrophins,
the GDNF family of neurotrophic factors, and the neuropoetic cytokines. Following a general overview of the mechanisms by
which these neurotrophic factors mediate their effects, we reviewed the temporal pattern of expression of the neurotrophic
factors and their receptors by axotomized motoneurons as well as in the distal nerve stump after peripheral nerve injury.
We discussed recent experiments from our lab and others which have examined the role of neurotrophic factors in peripheral
nerve injury. Although our understanding of the mechanisms by which neurotrophic factors mediate their effects in vivo are
poorly understood, evidence is beginning to emerge that similar phenomena observed in vitro also apply to nerve regeneration
in vivo. |
| |
Keywords: | NGF BDNF GDNF CNTF axon regeneration functional recovery Schwann cells motoneuron |
本文献已被 PubMed SpringerLink 等数据库收录! |
|