| 胃肠道间质瘤组织中MMP-13与CD147的表达及其意义 |
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| 引用本文： | 张薇,潘献柱,吴正升,吴强. 胃肠道间质瘤组织中MMP-13与CD147的表达及其意义[J]. 中国组织化学与细胞化学杂志, 2009, 18(6): 649-652. DOI: 10.3870/zgzzhx.2009.06.007 |
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| 作者姓名： | 张薇 潘献柱 吴正升 吴强 |
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| 作者单位： | 1. 安徽医学高等专科学校病理教研室,合肥,230061
2. 安徽医科大学病理解剖学教研室,合肥,230032 |
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| 基金项目： | 安徽省教育厅自然科学研究基金资助课题 |
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| 摘 要： | 目的探讨基质金属蛋白酶-13（Matrix metalloproteinases-13,MMP-13）和CD147的表达与胃肠道间质瘤（Gastrointestinals stromal tumors,GISTs）临床病理特征的关系。方法采用免疫组织化学检测69例GISTs组织中MMP-13及CD147的表达,分析MMP-13和CD147与各病理参数的关系。结果GISTs组织中MMP-13和CD147的表达率分别为95.7%和97.1%,MMP-13阳性表达程度与GISTs的生物学行为、CD147表达及肿瘤的大小呈正相关（P〈0.05）;CD147阳性表达程度与肿瘤的大小呈正相关（P〈0.05）。结论MMP-13表达与GISTs生物学行为关系密切,可作为GISTs生物学行为的潜在评价指标。
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| 关 键 词： | 胃肠道间质瘤 基质金属蛋白酶-13 CD147 免疫组化 组织芯片 |
EXPRESSIONS OF CD147 AND MATRIX METALLOPROTEINASE-13 IN GASTROINTESTINAL STROMAL TUMORS AND THEIR SIGNIFICANCE |
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| Zhang Wei,Pan Xianzhu, Wu Zhengsheng, Wu Qiang. EXPRESSIONS OF CD147 AND MATRIX METALLOPROTEINASE-13 IN GASTROINTESTINAL STROMAL TUMORS AND THEIR SIGNIFICANCE[J]. Chinese Journal of Histochemistry and Cytochemistry, 2009, 18(6): 649-652. DOI: 10.3870/zgzzhx.2009.06.007 |
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| Authors: | Zhang Wei Pan Xianzhu Wu Zhengsheng Wu Qiang |
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| Affiliation: | Zhang Wei1,Pan Xianzhu,1 Wu Zhengsheng,2 Wu Qiang2(1Department of Pathology,Anhui Medical College,Hefei 230061,China,2 Department of Pathoology,Anhui Medical University,Hefei 230032) |
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| Abstract: | Objective To investigate the relationship between the expression of matrix metalloproteinase-13 and CD147 and their clinical significance in gastrointestinal stromal tumors(GISTs).Methods 69 cases of GISTs were immunohistochemically studied for the expressions of MMP-13 and CD147 and their relations with every pathologic parameter were analyzed statistically.ResultsOut of 69 cases,the positivity of MMP-13 and CD147 was 95.7% and 97.1 % respectively.The expression degree of MMP-13 was significantly related t... |
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| Keywords: | CD147 Gastrointestinal stromal tumor (GIST) Matrix metalloproteinase (MMP)-13 CD147 Immunohistochemisty Tissue microarray |
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