Reduction by a model of NAD(P)H: XXIII. Kinetics for the reduction of 2-acylpyridines |
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| Authors: | Atsuyoshi Ohno Shinro Yasui Ronald A. Gase Shinzaburo Oka Upendra K. Pandit |
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| Affiliation: | Institute for Chemical Research, Kyoto University, Uji, Kyoto 611, Japan |
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| Abstract: | Kinetics for the reduction of 2-acetylpyridine and 2-benzoylpyridine with 1-benzyl-1,4-dihydronicotinamide in acetonitrile has been studied. Isotope effects of the reduction reveal that the transfer of hydrogen nucleus is involved in the rate-determining step. The effect of zinc ion on the reaction rate has been studied quantitatively and the true reacting species have been elucidated. |
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