Reactions of the vaginal plate and the vaginal epithelium to oestradiol monopropionate given once to 5 or 26-day old rats |
| |
Authors: | John-Gunnar Forsberg Dora Jacobsohn Allan Norgren |
| |
Institution: | (1) Tornblad Institute for Comparative Embryology, University of Lund, Sweden;(2) Departments of Anatomy and Physiology, University of Lund, Sweden |
| |
Abstract: | Summary Five-day old rats were given a single injection of varying amounts of oestradiol monopropionate (OeM) in propylene glycol (0.5, 5, 30 and 150 g) and 26-day old rats were given a single injection of 5 or 150 g OeM. The rats were sacrificed at varying times after the injection and the changes in the vaginal plate and the vaginal epithelium proper were studied. As indicated by the cornification of the epithelium the reaction to OeM is stronger in the vaginal plate than in the vaginal epithelium proper. The response of the vaginal epithelium to 5 or 150 g OeM is most extensive in the rats injected at 26 days of age. With 150 g OeM a cornification of the vaginal epithelium was obtained in rats injected when 26 days old but not in those injected when 5 days old. The reactions in the vaginal plate were compared with those found previously after injections of testosterone propionate.
Acknowledgement. This investigation was supported by grants from the Swedish Medical Research Council (12 X-579-03, K67-14X-571-03) and from the Swedish Cancer Society (67:46). |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|