The sequence, structure and evolutionary features of HOTAIR in mammals |
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| Authors: | Sha He Shiping Liu and Hao Zhu |
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| Institution: | (1) Bioinformatics Section, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China;(2) School of Biology, South China University of Technology, Guangzhou, 510510, China |
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| Abstract: | Background An increasing number of long noncoding RNAs (lncRNAs) have been identified recently. Different from all the others that function
in cis to regulate local gene expression, the newly identified HOTAIR is located between HoxC11 and HoxC12 in the human genome and
regulates HoxD expression in multiple tissues. Like the well-characterised lncRNA Xist, HOTAIR binds to polycomb proteins
to methylate histones at multiple HoxD loci, but unlike Xist, many details of its structure and function, as well as the trans regulation, remain unclear. Moreover, HOTAIR is involved in the aberrant regulation of gene expression in cancer. |
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