Effect of platelet-activating factor on the release of PGF-2 alpha and PGE-2 by separated cells of human endometrium |
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| Authors: | S K Smith R W Kelly |
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| Affiliation: | Medical Research Council Reproductive Biology Unit, Centre for Reproductive Biology, Edinburgh, U.K. |
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| Abstract: | Synthetic platelet-activating factor (PAF-acether, 1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine) caused a dose-dependent increase in the synthesis of prostaglandin (PG) E-2 by an enriched glandular, but not stromal, fraction of human endometrium removed in the secretory phase of the menstrual cycle. PAF-acether did not alter the synthesis of PGF-2 alpha by this fraction and consequently there was a significant reduction in the ratio of the amounts of PGF-2 alpha/PGE-2 released by the cells into the culture medium. The preimplantation human embryo secretes PAF, and these findings may have relevance to the local maternal recognition of pregnancy. |
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