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Acetylation of PAMAM dendrimers for cellular delivery of siRNA |
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| Authors: | Carolyn L Waite Sarah M Sparks Kathryn E Uhrich Charles M Roth |
| Affiliation: | (1) Department of Chemical and Biochemical Engineering, Rutgers University, Piscataway, NJ, USA;(2) Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ, USA;(3) Department of Biomedical Engineering, Rutgers University, Piscataway, NJ, USA |
| Abstract: | BackgroundThe advancement of gene silencing via RNA interference is limited by the lack of effective short interfering RNA (siRNA) delivery vectors. Rational design of polymeric carriers has been complicated by the fact that most chemical modifications affect multiple aspects of the delivery process. In this work, the extent of primary amine acetylation of generation 5 poly(amidoamine) (PAMAM) dendrimers was studied as a modification for the delivery of siRNA to U87 malignant glioma cells. |
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