Comparative characterization of mesenchymal stem cells from eGFP transgenic and non-transgenic mice |
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| Authors: | Cynthia B Ripoll and Bruce A Bunnell |
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| Institution: | (1) Department of Pharmacology, Tulane University Health Sciences Center, New Orleans, LA, USA;(2) Division of Gene Therapy, Tulane National Primate Research Center, Covington, LA, USA;(3) Center for Gene Therapy, Tulane University Health Sciences Center, New Orleans, LA, USA |
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| Abstract: | Background Adipose derived- and bone marrow-derived murine mesenchymal stem cells (mMSCs) may be used to study stem cell properties in
an in vivo setting for the purposes of evaluating therapeutic strategies that may have clinical applications in the future. If these
cells are to be used for transplantation, the question arises of how to track the administered cells. One solution to this
problem is to transplant cells with an easily identifiable genetic marker such as enhanced green fluorescent protein (eGFP).
This protein is fluorescent and therefore does not require a chemical substrate for identification and can be visualized in
living cells. This study seeks to characterize and compare adipose derived- and bone marrow-derived stem cells from C57Bl/6
mice and eGFP transgenic C57Bl/6 mice. |
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