Experimental verification of the model of complement-dependent immune lysis of liposomes |
| |
Authors: | S P Yarkov S N Skopinskaya |
| |
Institution: | 1.State Research Institute of Biological Engineering,Moscow,Russia |
| |
Abstract: | The quantitative dependences of the complement-dependent immune lysis of a monodisperse suspension of 200-nm liposomes sensitized
by a monovalent hapten (2,4-DNP-ɛ-caproyl-DPPE) or a polyvalent antigen (LPS from Francisella tularensis) on the initial concentration of specific antibodies (IgG) to the hapten and antigen have been investigated. The quantity
of antibody-binding sites on the liposome surface was evaluated. The difference between the complement-dependent lysis of
poly- and monodisperse suspensions of liposomes was shown. The experimental results are well described by the direct binding
model. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |