Biotechnology of succinic acid production and markets for derived industrial products |
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| Authors: | J G Zeikus M K Jain P Elankovan |
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| Institution: | (1) MBI International, 3900 Collins Road, Lansing, MI 48910, USA Tel.: +1-517-337-3181 Fax: +1-517-337-2122, US;(2) Michigan State University, Departments of Biochemistry and Microbiology, 410 Biochemistry Building, East Lansing, MI, USA Tel.: +1-517-353-4674 Fax: +1-517-353-9334, US |
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| Abstract: | Succinic acid, derived from fermentation of agricultural carbohydrates, has a specialty chemical market in industries producing
food and pharmaceutical products, surfactants and detergents, green solvents and biodegradable plastics, and ingredients to
stimulate animal and plant growth. As a carbon-intermediate chemical, fermentation-derived succinate has the potential to
supply over 2.7 × 108 kg industrial products/year including: 1,4-butanediol, tetrahydrofuran, γ-butyrolactone, adipic acid, n-methylpyrrolidone and linear aliphatic esters. Succinate yields as high as 110 g/l have been achieved from glucose by the
newly discovered rumen organism Actinobacillus succinogenes. Succinate fermentation is a novel process because the greenhouse gas CO2 is fixed into succinate during glucose fermentation. New developments in end-product recovery technology, including water-splitting
electrodialysis and liquid/liquid extraction have lowered the cost of succinic acid production to U.S. $ 0.55/kg at the 75 000
tonne/year level and to $ 2.20/kg at the 5000 tonne/year level. Research directions aimed at further improving the succinate
fermentation economics are discussed.
Received: 27 October 1998 / Received revision: 22 January 1999 / Accepted: 22 January 1999 |
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