<Emphasis Type="Italic">ABCA1</Emphasis> gene expression in peripheral blood lymphocytes and macrophages in patients with atherosclerosis |
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| Authors: | E P Demina V V Miroshnikova T I Rodygina P S Kurianov A G Vinogradov A D Denisenko A L Schwarzman |
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| Institution: | 1.St. Petersburg Nuclear Physics Institute,Russian Academy of Sciences,Gatchina, Leningradskaya oblast’,Russia;2.Pavlov State Medical University,St. Petersburg,Russia;3.St. Petersburg Institute of Experimental Medicine Russian Academy of Medical Sciences,St. Petersburg,Russia |
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| Abstract: | ABCA1 transporter is known to play an important role in cholesterol transport from peripheral tissues. However, its contribution
to atherosclerosis development remains obscure. Using Real Time PCR, we detected a significant reduction of ABCA1 mRNA level in leukocytes of patients with atherosclerosis compared to control. Mean ABCA1 expression levels in leukocytes from the group of patients and from the control group were 0.57 ± 0.28 and 0.93 ± 0.14 (p = 0.02). At the same time, we revealed a significant increase of ABCA1 mRNA level in macrophages of patients compared to control. Mean ABCA1 expression levels in macrophages from the group of patients and from the control group were 1.32 ± 0.10 and 0.90 ± 0.14 (p = 0.014). In summary, we suggest that the expression level of ABCA1 gene may regulate atherosclerosis development. |
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