Extrapineal N-acetyltransferase activity in rat brain |
| |
| Authors: | S M Paul L L Hsu A J Mandell |
| |
| Affiliation: | Department of Psychiatry, University of California, San Diego La Jolla, California 92037, USA |
| |
| Abstract: | An extrapineal enzyme that N-acetylates a variety of indole and catechol alkylamines, including the psychoactive drugs mescaline and d-amphetamine, has been partially purified from rat brain. This enzymatic activity has a distinct pH optimum, is linear with incubation time and protein concetration, and is abolished by heating. Purification is approximately ten fold with ammonium sulfate precipitation and column chromatography, yielding a specific activity of 7936 pmoles of product per mg of protein per hour with tryptamine as substrate. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
