Chitosan and hydroxyapatite composite cross‐linked by dopamine has improved anisotropic hydroxyapatite growth and wet mechanical properties |
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| Authors: | Ekavianty Prajatelistia Chanoong Lim Dongyeop X Oh Sang Ho Jun Dong Soo Hwang |
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| Institution: | 1. School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, Korea;2. POSTECH Ocean Science and Technology Institute, Pohang University of Science and Technology, Pohang, Korea;3. Division of Oral and Maxillofacial Surgery, Department of Dentistry, Korea University Anam Hospital, Seoul, Korea;4. Integrative Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, Korea;5. School of Environmental Science and Engineering, Pohang University of Science and Technology, Pohang, Korea |
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| Abstract: | Three of the major impediments to using hydroxyapatite (HAp)‐collagen composites for hard tissue repair are the difficulties in anisotropic growth of HAp, in functional collagen production, and in their cross‐linking. To solve these problems, we fabricated HAp‐based composites for hard tissue repair by using chitosan as a collagen matrix substitute, and dopamine as a replacement for aldehyde‐based cross‐linkers. In the presence of chitosan and dopamine, the HAp particles grew anisotropically in a needle shape with an aspect ratio of ～4.4. The needle‐shaped HAp particles were dispersed well in the chitosan matrix, and dopamine‐mediated cross‐linking enhanced the stiffness and reduced swelling in the presence of water. The composite is too weak for use in hard tissue repair, but could be used for curing dentin sensitivity by blocking and remineralization on dentinal tubules, and in drug‐delivery applications. |
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| Keywords: | Aspect ratio Anisotropic growth Chitosan Dopamine Hydroxyapatite |
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