Modulation of Phosphorylation of Neuronal Cytoskeletal Proteins by Neuronal Depolarization |
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Authors: | Marina Mata Paul Honegger David J Fink |
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Institution: | (1) Department of Neurology, University of Pittsburgh USA, and Neurology Research Laboratory, VAMC, Pittsburgh, Pennsylvania;(2) Institute of Physiology, University of Lausanne, Lausanne, Switzerland |
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Abstract: | 1. The neuronal cytoskeletal protein tau and the carboxy tails of cytoskeletal proteins neurofilament-M (NF-M) and neurofilament-H (NF-H) are phosphorylated on serine residues by the cyclin-dependent kinase cdk-5.2. In aggregating neuronal–glial cultures we show that veratridine-mediated cation influx causes dephosphorylation of tau, NF-M and NF-H. Dephosphorylation was blocked specifically by cyclosporine A but not by okadiac acid at concentrations up to 200 nM.3. These results suggest that veratridine-triggered cation influx causes activation of PP-2B (calcineurin) leading to dephosphorylation of these cytoskeletal proteins. |
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Keywords: | neurofilament tau kinase phosphatase calcineurin |
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