Dihydro-[1H]-quinolin-2-ones as retinoid X receptor (RXR) agonists for potential treatment of dyslipidemia |
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| Authors: | Lagu Bharat Lebedev Rimma Pio Barbara Yang Maria Pelton Patricia D |
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| Affiliation: | Johnson and Johnson Pharmaceutical Research and Development, Cranbury, NJ 08512, USA. bharat.lagu@novartis.com |
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| Abstract: | A number of RXR modulators with novel structural features were synthesized and screened in the functional assays. The synthesis and the structure-activity relationship within the series of compounds will be presented. Some in vivo data generated in the models for dyslipidemia and diabetes will also be presented. |
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