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SAR in the alkoxy lactone series: the discovery of DFP, a potent and orally active COX-2 inhibitor. |
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| Authors: | Y Leblanc P Roy S Boyce C Brideau C C Chan S Charleson R Gordon E Grimm J Guay S Léger C S Li D Riendeau D Visco Z Wang J Webb L J Xu P Prasit |
| Affiliation: | Merck Frosst Centre for Therapeutic Research, Québec, Canada. |
| Abstract: | Extensive SAR has been established in the alkoxy lactone series and this has lead to the discovery of DFP (5,5-dimethyl-3-(2-propoxy)-4-methanesulfonylphenyl)-2(5H)-furanon e), a potent COX-2 inhibitor exhibiting in vivo efficacy in all models studied. |
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