Blood manganese levels in children with convulsive disorder |
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| Authors: | C L Dupont Y Tanaka |
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| Affiliation: | 1. Department of Informatics, Aristotle University of Thessaloniki, Thessaloniki, Greece;2. Faculty of Information Technology and Communication, Tampere University, Tampere, Finland;3. Electrical and Computer Engineering, Aarhus University, Aarhus, Denmark;1. São Paulo State University (Unesp), School of Agricultural and Veterinarian Sciences. Via de Acesso Prof. Paulo Donato Castellane s/n, Jaboticabal – SP 14884-900, Brazil;2. Department of Animal Sciences, University of Wisconsin-Madison. 436 Animal Science Building, 1675 Observatory Dr. Madison – WI 53706, United States;3. Empresa Brasileira de Pesquisa Agropecuária, Embrapa Cerrado. BR-020, km 18, s/n, Planaltina, Brasília – DF 73310-970, Brazil;4. Empresa Brasileira de Pesquisa Agropecuária, Embrapa Pecuária Sudeste. Rodovia Washington Luiz, Km 234 s/nº, Fazenda Canchim, CP 339, São Carlos – SP 13560-970, Brazil;5. Federal University of Rio Grande do Sul (UFRGS). Av. Paulo Gama, 110 - Farroupilha, Porto Alegre – RS 90040-060, Brazil;6. Empresa Brasileira de Pesquisa Agropecuária, Embrapa Pecuária Sul. Rodovia BR-153, Km 632,9 Vila Industrial, Zona Rural, CP 242 Bagé – RS 96401-970, Brazil;7. Empresa Brasileira de Pesquisa Agropecuária, Embrapa Recursos Genéticos e Biotecnologia. Parque Estação Biológica, PqEB, Av. W5 Norte (final), CP 02372, Brasília – DF 70770-917, Brazil |
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| Abstract: | Manganese deficiency syndromes have been well described in animals and include among a wide variety of metabolic aberrations the heightened susceptibility to convulsions induced by electroshock or drugs. We have measured manganese blood levels in two populations of children: (1) a reference group of 120 ambulatory patients without neurologic disease, (2) 197 patients with convulsive disorder. Blood manganese was found to be age related in infants under 1 year of age. Highly significant was the lower mean blood manganese found in the convulsive disorder group as compared to the reference group. There was also a slight trend in the convulsive group for blood manganese to decrease from 1 to 22 years of age. No significant differences in manganese levels were found related to sex, type of seizure disorder, type of anticonvulsant drug therapy, or serum level of drug. Although this study does not demonstrate a causal relation between manganese and seizure disorder, and cannot be used as the basis for altering current approaches to therapy, it provides insight into the potentially important role of previously unrecognized factors in the pathophysiology of this syndrome. |
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