Identification of a transforming gene of human papillomavirus type 16. |
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| Authors: | A Tanaka T Noda H Yajima M Hatanaka and Y Ito |
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| Institution: | Institute for Virus Research, Kyoto University, Japan. |
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| Abstract: | Previously, we observed sequential two-step alteration, growth stimulation, and progression to a more malignant state in NIH 3T3 cells transfected by human papillomavirus type 16 (HPV-16) DNA. In this study, we prepared a cDNA library from RNA extracted from cells transfected with the HPV-16 DNA and isolated cDNA clones which had growth-stimulating activity. Analysis of these cDNA clones indicated that the E7 open reading frame alone is responsible for inducing both steps of this cell transformation. |
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