Biosynthesis of methyl chloride in the fungusPhellinus pomaceus |
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| Authors: | Robert H White |
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| Institution: | (1) Department of Biochemistry and Nutrition, Virginia Polytechnic Institute and State University, 24061 Blacksburg, VA, USA |
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| Abstract: | The biosynthetic origin of themethyl group in the methyl chloride produced by cultures ofPhellinus pomaceus (Pers.) Maire has been investigated using stable isotope labeled substrates. Feeding ofd-6,6-2H2] glucose,Dl-3,3-2H2] serine andl-methyl-2H3] methionine led to the production of deuterated methyl chloride in which the major labeled species contained 2, 2, and 3 deuterium atoms, respectively. The data are consistent with the methyl chloride produced by this organism being derived solely from methionine with retention of all of the methyl protons.Abbreviation SAM
S-adenosylmethionine
- FH4
tetrahydrofolate
- N5-CH3FH4
N5-methyltetrahydrofolate
- B12
cobalamin |
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| Keywords: | Methyl halides Biosynthesis Stable isotopes Basidiomycetes Phellinus pomaceus |
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