A novel type of human alpha-amylase produced in lung carcinoid tumor |
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| Authors: | N Tomita A Horii S Doi H Yokouchi K Shiosaki M Higashiyama N Matsuura M Ogawa T Mori K Matsubara |
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| Affiliation: | Institute for Molecular and Cellular Biology, Osaka University, Japan. |
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| Abstract: | A novel type of alpha-amylase was detected in a lung carcinoid tissue after surveying the cDNA library constructed from this tumor mRNA. Nucleotide sequence analysis showed that the amylase expressed in this carcinoid tumor has 13 and 6 amino acid substitutions when compared with salivary amylase (Amy1) and pancreatic amylase (Amy2), respectively. The nucleotide sequence homologies of cDNAs between this carcinoid amylase and amy1, amy2 are 97.5% and 98.2%, respectively. The nucleotide sequence comparison strongly suggests that this new amylase is the product of the amy3 gene that has been detected in human genome [Emi et al., Gene 62 (1988) 229-235] |
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