The effects of paradoxical sleep deprivation on estrous cycles of the female rats |
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Authors: | Antunes Isabela B Andersen Monica L Baracat Edmundo C Tufik Sergio |
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Affiliation: | Department of Psychobiology, Universidade Federal de S?o Paulo, Escola Paulista de Medicina, UNIFESP/EPM, Rua Napole?o de Barros, 925, Vila Clementino 04024-002, S?o Paulo, SP, Brazil. |
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Abstract: | The present purpose was to examine how sleep deprivation affects the estrous cycle of the female rat. Paradoxical sleep-deprived (PSD) adult female Wistar rats were compared to home-cage control (CTRL) on their estrous cyclicity. Forty-four PSD and forty-four CTRL female rats were distributed into 4 subgroups of 11 animals each according to the phase of estrous cycle and were subjected to sleep deprivation for 96 h by the multiple platform technique. After PSD period, vaginal estrous cycles were taken for an additional 9 days. Animals that were submitted to PSD in diestrus phase (PSD-diestrus) had their estrous cycles disrupted during the recovery period by showing a constant diestrus during the first week. As for hormone alterations, progesterone concentrations were statistically higher in PSD-diestrus compared to respective phase control and to PSD-proestrus and PSD-estrus rats while CTRL-metestrus had higher levels than CTRL-proestrus and estrus groups. Testosterone was significantly decreased in PSD-estrus in relation to PSD-proestrus and PSD-diestrus groups and was lower in CTRL-diestrus rats than in home-cage rats in proestrus. In addition, PSD-diestrus phase exhibited higher concentrations of corticosterone and lower estrogen than the respective control rats. These data indicate that PSD may modulate the ovarian hormone release through alterations in hormonal-neurochemical mechanisms. |
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Keywords: | Sleep deprivation Estrous cycle Recovery Progesterone Female rat |
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