Reoxygenation Injury of Human Brain Capillary Endothelial Cells |
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| Authors: | Tatsuya Nagashima Shijing Wu Michio Yamaguchi Norihiko Tamaki |
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| Affiliation: | (1) Department of Neurosurgery Kobe University School of Medicine, 5-1, Kusunoki-cho 7 Chome, Chuo-ku, 650 Kobe, Japan;(2) Faculty of Health Science, Kobe University School of Medicine, Kobe, Japan |
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| Abstract: | 1. Many studies have demonstrated that endothelial cells from several species can generate oxygen free radicals when subjected to anoxia and reoxygenation. However, due to the heterogeneity of the endothelium within different organs and species, the effects of superoxide dismutase (SOD), catalase, and allopurinol on reoxygenated cultured cells remain quite controversial.2. This review outlines the possible sources of oxygen free radicals within brain endothelial cells.3. We examine the aspects of the effects of SOD catalase and allopurinol on cultured human brain capillary endothelial cells upon reoxygenation.4. Also, we introduce briefly a method of culturing human brain capillary endothelial cells and present our experimental results on the effects of SOD, catalase, and allopurinol in these cultured cells following anoxia and reoxygenation. |
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| Keywords: | reoxygenation free radicals brain capillary endothelial cells |
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