|
|||||
|
|
DNA polymerase clamp loaders and DNA recognition |
|
| Authors: | Bowman Gregory D Goedken Eric R Kazmirski Steven L O'Donnell Mike Kuriyan John |
| Institution: | Departments of Molecular and Cell Biology and Chemistry, Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA. |
| Abstract: | Clamp loaders are heteropentameric ATPase assemblies that load sliding clamps onto DNA and are critical for processive DNA replication. The DNA targets for clamp loading are double-stranded/single-stranded junctions with recessed 3' ends (primer-template junctions). Here, we briefly review the crystal structures of clamp loader complexes and the insights they have provided into the mechanism of the clamp loading process. |
| Keywords: | DNA sliding clamp Clamp loader AAA+ ATPase Primer-template junction DNA replication |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |