Hydrodynamic delivery of IL-38 gene alleviates obesity-induced inflammation and insulin resistance |
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Authors: | Keye Xu Jun Sun Sisi Chen Yuan Li Xiao Peng Mingcai Li Yan Li |
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Institution: | u166. Department of Immunology, Medical School of Ningbo University, Ningbo, 315211, China |
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Abstract: | Obesity is associated with a chronic inflammatory response. Interleukin (IL)-38 is a poorly characterized cytokine of the IL-1 family with anti-inflammatory activity. The role of IL-38 in obesity-induced inflammation and insulin resistance remains unknown. In this study, we investigated the effects of IL-38 expression by hydrodynamic-based gene delivery on high-fat diet-induced obesity in mice. Transfer of plasmid DNA encoding IL-38 reduced weight gain, liver fat content, adipose tissue weight, and obesity-induced insulin resistance compared with administration of a control plasmid. Moreover, IL-38 gene delivery inhibited the production of inflammatory mediators including IL-1β, IL-6, and monocyte chemotactic protein-1. These results suggest that IL-38 is a potential new target for the treatment of obesity. |
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Keywords: | IL-38 Obesity High-fat diet Inflammation Insulin resistance |
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