LncRNA LCPAT1 is involved in DNA damage induced by CSE |
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| Authors: | Sumeng Gao Hongyan Lin Wang Yu Fangfang Zhang Ruoyang Wang Herbert Yu Biyun Qian |
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| Affiliation: | 1. Hongqiao International Institute of Medicine, Shanghai Tongren Hospital and Faculty of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China;2. Cancer Epidemiology Program, University of Hawaii Cancer Center, 701 Ilalo Street, Honolulu, USA |
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| Abstract: | Cigarette smoking plays an important role in the process of lung cancer, during which DNA damage is proved to be involved. Non-coding RNAs are found to be involved in the DNA damage and repair processes induced by cigarette smoke. In the present study, we investigated the role of lncRNA LCPAT1 in DNA damage caused by CSE in Beas-2B cells. Our results indicate that LCPAT1, through RCC2 is involved in the CSE-induced DNA damage providing new insight into the lung carcinogenesis related to cigarette smoking. |
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| Keywords: | Cigarette smoke DNA damage Lung carcinogenesis LCAPT1 |
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