The role of conventional antibodies targeting the CD4 binding site and CD4-induced epitopes in the control of HIV-1 CRF01_AE viruses |
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| Authors: | Win Thida Takeo Kuwata Yosuke Maeda Tetsu Yamashiro Giang Van Tran Kinh Van Nguyen Masafumi Takiguchi Hiroyuki Gatanaga Kazuki Tanaka Shuzo Matsushita |
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| Institution: | 1. Center for AIDS Research, Kumamoto University, Kumamoto, Japan;2. Department of Microbiology, Kumamoto University, Kumamoto, Japan;3. Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan;4. National Hospital of Tropical Diseases, Dong Da District, Hanoi, Viet Nam;5. AIDS Clinical Center, National Center for Global Health and Medicine, Tokyo, Japan |
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| Abstract: | HIV-1 CRF01_AE viruses are highly prevalent in Southeast Asia. However, vulnerability sites in Env of CRF01_AE viruses have not been investigated sufficiently. We examined the sensitivity of CRF01_AE viruses from Japan and Vietnam, together with subtype B viruses from Japan, to neutralization and Fc-mediated signaling. Neutralization coverage of broadly neutralizing antibodies (bnAbs), 2G12 and b12, was significantly low against CRF01_AE viruses, compared with subtype B viruses. In contrast, the conventional antibody targeting the CD4 binding site (CD4bs), 49G2, showed better neutralization and Fc-mediated signaling activities against CRF01_AE viruses than subtype B viruses. Fc-mediated signaling activity of anti-CD4 induced (CD4i) antibody, 4E9C, was also detected against CRF01_AE viruses more than subtype B viruses. These results suggest that conventional antibodies against CD4bs and CD4i may play an important role in the control of CRF01_AE viruses. |
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| Keywords: | HIV-1 CRF01_AE Antibody Neutralization Fc-mediated signaling |
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