Chemical speciation in wound fluid leading to enhanced bioavailability for healing |
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| Authors: | Janitha A Liyanage David M Taylor David R Williams |
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| Institution: | Department of Chemistry, University of Wales, Cardiff, PO Box 912, Cardiff CF1 3TB, UK. |
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| Abstract: | ABSTRACTECCLES computer modelling is used to speciate Ca2+, Zn2+, Cu2+, Mn2+ and Fe3+ in wound fluid samples analysed for total metal content using Potentiometric stripping analysis. Bioavailability of metals, related to lipid soluble net-neutral complexes, was assessed and found to be broadly similar to the speciation in blood plasma. These appear to be benefits worthy of clinical investigation of keeping the wound fluid at pH = 6.4 and of raising the total cysteine concentration levels in wound fluid. |
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| Keywords: | Wound management healing |
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