Functional role of soluble mitochondrial ATPase subunits |
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Authors: | I. A. Kozlov A. A. Kondrashin V. A. Kononenko S. T. Metelsky |
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Affiliation: | (1) Department of Bioenergetics, Laboratory of Bioorganic Chemistry, Moscow State University, 117234 Moscow, U.S.S.R. |
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Abstract: | A preparation of soluble mitochondrial ATPase (coupling factor F1) containing no and minor subunits has been isolated. The minor-subunits-deficient F1 was found to be competent in ATP hydrolysis. However, it did not demonstrate a coupling effect in EDTA-submitochondrial particles. A portion of the ATPase activity of EDTA particles, stimulated by the minor-subunits-deficient F1, was insensitive to oligomycin. ATPase activity of Na+-particles was changed only slightly by this F1. It is suggested that and subunits are necessary to form specific contacts between the F1 molecule and components of the mitochrondrial membrane.Abbreviations SMP submitochondrial particles - F1 coupling factor (soluble mitochondrial ATPase) - PCB– phenyl dicarbaundecaborane anions |
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