Autoradiographic localization of vitamin A in the adrenal gland of rats. |
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Authors: | D L Wallace C G Plopper T J Bucci H E Sauberlich |
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Institution: | Letterman Army Institute of Research Presidio of San Francisco, CA 94129, U.S.A. |
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Abstract: | Cellular distribution of vitamin A in the rat adrenal was evaluated by autoradiography. Vitamin A was concentrated in the lipid droplets of epithelial cells of the zona fasciculata and zona reticularis. A small amount of vitamin A was also present in the cytoplasm and nucleus of these cells. The zona glomerulosa contained very little vitamin A either in lipid droplets or in the remainder of the cell. The medulla had essentially no vitamin A. Such strong cellular specificity for uptake of vitamin A by the cells of the zona fasciculata and zona reticularis supports the hypothesis that vitamin A is involved in synthesis of glucocorticoid hormones. |
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