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Regulation of GSK3 isoforms by phosphatases PP1 and PP2A |
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| Authors: | Félix Hernández Elena Langa Raquel Cuadros Jesús Avila Nieves Villanueva |
| Institution: | 1. Centro de Biologia Molecular “Severo Ochoa” (CSIC-UAM), Campus de Cantoblanco, 28049, Madrid, Spain 2. CIBERNED, 28031, Madrid, Spain 3. Centro Nacional de Microbiología, Instituto de Salud Carlos III, Ctra. Majadahonda, 28220, Madrid, Spain |
| Abstract: | Dephosphorylation of phospho GSK3 isoforms, from COS-7 cells, was determined in vitro and in cultured cells in the absence or the presence of okadaic acid and lithium. Our results indicate a preferential dephosphorylation of phospho GSK3α by PP2A phosphatase, whereas dephosphorylation of phospho GSK3β mainly takes place by PP1 phosphatase. |
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