Comparative analysis of the human dystrophin and utrophin gene structures |
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Authors: | Pozzoli Uberto Sironi Manuela Cagliani Rachele Comi Giacomo P Bardoni Alessandra Bresolin Nereo |
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Institution: | IRCCS E. Medea, Associazione La Nostra Famiglia, 23842 Bosisio Parini, LC, Italy. msironi@bp.lnf.it |
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Abstract: | We present analysis of intronic sequences in the human DMD and UTRN genes. In both genes accumulation of repeated elements could account for intron expansion. Out-of-frame rod-domain exons have stronger splice sites and are separated by significantly longer introns as compared to in-frame exons. These features are unique for the two homologs and not shared by other spectrin superfamily genes. |
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