Studies of cyclic AMP action using mutant tissue culture cells |
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| Authors: | Philip Coffino Henry R. Bourne Paul A. Insel Kenneth L. Melmon Gary Johnson Josefina Vigne |
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| Affiliation: | (1) Division of Clinical Pharmacology, Department of Medicine, University of California, San Francisco, 94143 San Francisco, California;(2) Department of Microbiology, University of California, San Francisco, 94143 San Francisco, California;(3) Cardiovascular Research Institute, University of California, San Francisco, 94143 San Francisco, California;(4) Deparment of Pharmacology, University of California, San Francisco, 94143 San Francisco, California |
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| Abstract: | Summary S49 mouse lymphoma cell mutants, each with a specific defect in its ability to generate or respond to cyclic AMP, have been isolated. Analysis of the properties of these cells has begun to provide information on complex and significant biologic problems related to the cyclic AMP system. Presented in the Opening Symposium on Nutritional Factors and Differentiation at the 28th Annual Meeting of the Tissue Culture Association, New Orleans, Louisiana, June 6–9, 1977. The work was supported in part by National Science Foundation Grant BMS 75-06764 and National Institutes of Health Grants GM 16496 and GM 00001. P.C. is the recipient of National Institutes of Health Research Career Development Award GM 00308. P. A. I. is an Established Investigator of the American Heart Association. |
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| Keywords: | somatic genetics hormones receptors protein kinase |
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