Subcellular Localization of Bioactive Cholecystokinin-Like Peptides in the Rat Cerebral Cortex |
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| Authors: | Andrea Varró ,J. Lonovics&dagger ,F. Hajnal&dagger ,J. Somogyi |
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| Affiliation: | Department of Biochemistry I., Semmelweis University Medical School, Budapest;Department of Medicine I., University Medical School, Szeged, Hungary |
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| Abstract: | Abstract: The subcellular distribution of cholecystokinin (CCK), especially its exact localization within the synaptosome, was studied in the rat cerebral cortex. Highest CCK-like bioactivity was measured in the synaptic membrane fractions, paralleling the distribution of (Na++ K+)-dependent ATPase. In the synaptic vesicles, which were characterized by high acetylcholine content and by the absence of (Na++ K+)-ATPase, only minimal quantities of CCK were detected. |
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| Keywords: | Cholecystokinin Synaptic membranes (Na++ K+)-ATPase Acetylcholine Synaptic vesicles |
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