Inactivation of the fliY gene encoding a flagellar motor switch protein attenuates mobility and virulence of Leptospira interrogans strain Lai |
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| Authors: | Sumei Liao Aihua Sun David M Ojcius Senlin Wu Jinfang Zhao and Jie Yan |
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| Institution: | (1) College of Life Sciences, Zhejiang University, 310058 Hangzhou, PR China;(2) Department of Medical Microbiology and Parasitology, College of Medicine, Zhejiang University, 310058 Hangzhou, PR China;(3) Zhejiang Medical College, 310058 Hangzhou, PR China;(4) Health Sciences Research Institute and School of Natural Sciences, University of California, 95343 Merced, CA, USA |
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| Abstract: | Background Pathogenic Leptospira species cause leptospirosis, a zoonotic disease of global importance. The spirochete displays active rotative mobility which
may contribute to invasion and diffusion of the pathogen in hosts. FliY is a flagellar motor switch protein that controls
flagellar motor direction in other microbes, but its role in Leptospira, and paricularly in pathogenicity remains unknown. |
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