Cellular localization of cystic fibrosis transmembrane regulator protein in piglet and mouse intestine |
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Authors: | Ursula L Hayden Hannah V Carey |
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Institution: | (1) Department of Comparative Biosciences, University of Wisconsin, School of Veterinary Medicine, 2015 Linden Drive West, Madison, WI 53706, USA, US |
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Abstract: | Antibodies raised against the cystic fibrosis transmembrane regulator protein (CFTR) were used to localize CFTR in intestinal
tissues of piglets and mice. Positive staining for CFTR was detected in goblet cells of both species. A second population
of epithelial cells of unknown phenotype was also labeled by anti-CFTR antibodies. The labeling pattern was abolished by preincubation
of anti-CFTR antibodies with the immunogen or when non-immune IgG was used in place of anti-CFTR antibodies. These results
support other studies that suggest that alterations in goblet cell function may be involved in the intestinal abnormalities
associated with cystic fibrosis.
Received: 4 May 1995 / Accepted: 6 September 1995 |
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Keywords: | : Cystic fibrosis transmembrane regulator Cystic fibrosis Intestine Mucus secretion Pig Mouse |
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