Synthesis and structure-activity relationships of a new class of selective EP3 receptor agonist, 13,14-didehydro-16-phenoxy analogues of prostaglandin E1 |
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| Authors: | Shimazaki Y Kameo K Tanami T Tanaka H Ono N Kiuchi Y Okamoto S Sato F Ichikawa A |
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| Affiliation: | Medicinal Research Center, Taisho Pharmaceutical Co., Ltd., Ohmiya, Saitama, Japan. s14801@ccm.taisho.co.jp |
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| Abstract: | A series of 13,14-didehydro-16-phenoxy analogues of prostaglandin E1 was synthesized and their agonistic activity on EP receptor subtypes was evaluated. 13,14-Didehydro-16-phenoxy-1-decarboxy analogues, 7e and 7f, display highly selective activity on the EP3 receptor subtype, thus, their utility as a selective anti-ulcer agent can be expected. |
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