Suppression of GD1alpha ganglioside-mediated tumor metastasis by liposomalized WHW-peptide |
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| Authors: | Takikawa M Kikkawa H Asai T Yamaguchi N Ishikawa D Tanaka M Ogino K Taki T Oku N |
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| Institution: | Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Japan. |
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| Abstract: | GD1alpha ganglioside-replica peptides were recently isolated from a phage-displayed random pentadecapeptide library by assaying for inhibition of adhesion of RAW117-H10 lymphosarcoma cells to hepatic sinusoidal microvessel endothelial (HSE) cells. We show here that the Trp-His-Trp (WHW) peptide was identified as a minimal sequence of the GD1alpha-replica peptide WHWRHRIPLQLAAGR. The addition of WHW peptide-attached liposomes displayed efficient inhibition of liver metastasis of RAW117-H10 cells as well as of GD1alpha-mediated adhesion of RAW117-H10 cells to HSE cells in vitro. These results suggest that engineered liposomes for peptide delivery are applicable to treatment for metastasis. |
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