Modulation of cell calcium signals by mitochondria |
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Authors: | Jouaville Laurence S. Ichas François Mazat Jean-Pierre |
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Affiliation: | (1) Laboratoire GESBI, Université Victor Ségalen, Bordeaux 2, 146 rue Léo Saignat, F-33076 Bordeaux-Cédex, France |
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Abstract: | It is now clearer and clearer that mitochondria play a role, and perhaps an active role, in cell calcium signalling. The fact that mitochondria can exhibit a Ca2+>-induced Ca2+> release (mCICR, Ichas et al. [37]) reinforces this concept and makes the mitochondria an essential element in the relay of Ca2+> wave propagation. It must be emphasized that the modulation of cell Ca2+> signals by mitochondria depends upon their energetic status, thus making mitochondria an essential link between energy metabolism and calcium signalling inside the cell. |
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Keywords: | cell calcium signalling mitochondria permeability transition pore (PTP) calcium waves |
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